Genocea has used ATLAS™ to recreate the T cell immune responses, in vitro, in hundreds of human subjects to each protein in the C. trachomatis proteome. Through this, Genocea has identified a small subset of T cell antigens that appear, in animal models, to reduce bacterial burden and prevent re-infection.
There is no vaccine for Chlamydia. Despite the availability of antibiotic treatment, Chlamydia remains a significant global health problem; the consequences of lack of treatment can be devastating. Often the infection is silent, and therefore goes untreated, leading to severe consequences. The disease is the most common cause of preventable blindness worldwide, with eight million people visually impaired or blind. Up to 40 percent of untreated women develop pelvic inflammatory disease, which can lead to infertility, ectopic pregnancies, and chronic pelvic pain. Chlamydia can also cause genitourinary and rectal conditions in men.