We are seeking an innovative Research Associate to join our team developing novel cellular immunotherapies. Genocea’s foundational technology, the ATLAS™ platform, is a high-throughput autologous cell assay that discovers T cell antigens thought to be important in fighting a patient’s disease. ATLAS™ results are used to select validated neoantigens for a patient-specific vaccine, and upon population-based screening can identify antigens to include in a common vaccine.
The successful candidate will help to advance Genocea’s approach to adoptive T cell therapy with clinical application in immuno-oncology and will help advance the next generation of ATLAS screening. The Research Associate will contribute to execution and analysis of cell culture studies focused on optimizing processes for T cell expansion and ATLAS screening. The position is lab-based and will work in collaboration with other team members. The ideal candidate is a motivated, energetic, detail-oriented person who will design and carry out experiments with limited supervision. Demonstrated hands-on experience with cell culture and immunological assays, such as ICS, ELISPOT, cell sorting, immunophenotyping and flow cytometry is a plus.
Develop method for isolation and expansion of human T cells including immune cell enrichment, T cell culture, APC differentiation and maturation and cryopreservation
Develop, optimize and qualify immunological and analytical methods to support process development such as ICS, proliferation, ELISA, cytotoxicity and multi-color flow cytometry assays
Follow new developments and technologies in the field of immuno-oncology
Excellent ability to perform hands on experiments and maintain detailed documentation
Excellent organizational skills and ability to multi-task and embrace change in an extremely fast-paced environment
Independently motivated, detail oriented and good problem-solving ability
Ability to work as part of a team, collaborating and communicating effectively with members of other functional groups
A sense of humor is essential
A solid theoretical understanding of and experience with immunology techniques. Assay development experience is a plus.
Ability to work independently and as a part of a cross-functional team with a positive attitude.
Strong verbal and written communication skills are required.
Ability to analyze data, draw conclusions, communicate results and compile technical reports.
Excellent record keeping abilities to adequately record and document analytical data.
Solid technical knowledge and hands-on experience.
Capacity to adapt, with a strong desire to learn new concepts and techniques
Experience with multi-color flow cytometry and flow data analysis is a plus
Excellent computer skills and experience with Microsoft Excel, Flow cytometry data analysis software, and Graphpad Prism are essential
Master’s degree or Bachelor’s degree with a minimum of 1 years of experience in biopharmaceutical industry
*in-house recruiting only*