Director, Financial Planning & Analysis

Position Summary

Genocea is looking to hire a proactive and dedicated Director of FP&A to join our fast-paced Finance team. In this position, you will be responsible for business partnering with both early stage and clinical R&D functions while supporting Genocea's business planning processes (budget/forecast and long range strategic planning).

Primary Responsibilities

  • Take a leadership role in the development of the annual and long-range plan and budget process

  • Prepare, analyze, and review periodic company-wide forecasts, annual budgets and multi-year budgets, including monthly P&L and cash flow actual vs. budget performance reports

  • Provide financial analysis/modeling support for the management team in preparation of business cases to support program resource allocation decisions and special projects as needed

  • Assist the CFO in supporting internal business partners including monthly budget vs. actual variance reporting

  • Implement Oracle PBCS in collaboration with Controller

  • Support the CFO in the creation and maintenance of in-depth program valuations and modeling to guide go/no go decision points during annual portfolio reviews

  • Perform other related duties and ad-hoc projects as required

Competencies

  • Strong project management and organizational skills

  • Ability and willingness to meet business critical deadlines

  • Strong analytical, problem solving and financial troubleshooting skills

  • Good interpersonal skills, including ability to translate financial concepts to individuals at all levels, including finance and non-finance managers

  • Strategic forward thinker with ability to see the big picture and communicate key insights to high level Executives

Education & Experience Required

  • Bachelor's degree in Accounting, Finance, or Business Administration

  • 8+ years of experience in Financial Planning or combination of FP&A/accounting for Life Sciences

  • 3+ years supporting Pharmaceutical/Biotech R&D

  • MBA or CPA strongly preferred

  • Experience with NetSuite preferred

  • Expert Microsoft Excel skills

Scientist, Cellular Biology & Immunology

Position Summary

We are seeking an innovative Scientist to join our team developing novel vaccine and cellular immunotherapies for treatment of cancer.  Genocea’s foundational technology, the ATLAS™ platform, is a high-throughput autologous cell assay that discovers tumor-specific T cell neoantigens thought to be important in controlling a patient’s disease.  ATLAS™ results are used to select validated neoantigens for patient-specific vaccines, population-based screening to identify antigens for inclusion in a common vaccine and for in vitro T cell expansion for adoptive immunotherapy. 

The successful candidate will advance Genocea’s approach to adoptive T cell therapy with clinical application in immuno-oncology, help advance the next generation of ATLAS screening and drive exploratory immunology projects.  The Scientist will design, develop, execute and analyze experiments to optimize processes for T cell expansion, and ATLAS screening and immunological cell-based assays.  The position is lab-based and will work in collaboration with other teams.  Activities stemming from early stage process development to later stage interactions with CMOs for technical transfer will be included in this role.  The Scientist will have the ability to independently troubleshoot technical issues and develop optimized processes and assays for critical tasks.  The successful candidate will have a strong background in immunology and T cell biology.  The scientist will have demonstrated hands-on experience with cell culture and immunological assays, such as ICS, ELISPOT, cell sorting, immunophenotyping and flow cytometry.  The candidate will have demonstrated leadership and managerial experience of a successful team.

Primary Responsibilities

  • Scientific leadership of a team of scientists and research associates to execute on goals of advancing ATLAS, adoptive T cell therapy and immunological cell-based assays

  • Drive innovative immunology and cell biology research

  • Develop method for isolation and expansion of human T cells including immune cell enrichment, T cell culture, APC differentiation and maturation and cryopreservation

  • Develop, optimize and qualify immunological and analytical methods to support process development such as ICS, proliferation, ELISA, cytotoxicity and multi-color flow cytometry assays

  • Develop and optimize assays to support exploratory clinical biomarker discovery

  • Design and perform DOE experiments to further characterize and optimize cellular expansion

  • Interact with CRO/CMOs for method transfer, technical advice and review of reports and data

  • Follow new developments and technologies in the field of immuno-oncology.

  • Key member of the research and cross-functional program teams, contributing to strategy with senior management

Competencies

  • Excellent ability to perform hands on experiments, research, design, and organize project designs and maintain detailed documentation

  • Excellent organizational skills and ability to multi-task and embrace change in an extremely fast-paced environment

  • Independently motivated, detail oriented and good problem-solving ability

  • Ability to work as part of a team, collaborating and communicating effectively with members of other functional groups

  • Strong writing, editing and presentation skills required

  • Excellent communications skills and a demonstrated ability to work in a matrix environment while establishing and maintaining effective collaborations is required

  • A sense of humor is essential

Required Skills

  • Expertise and hands-on experience in mammalian cell culture with specific experience culturing primary T lymphocytes is a requirement

  • Strong background in T cell biology and immunology is required, with background in oncology a plus

  • Demonstrated experience with immunological assays to assess and characterize T cell function such as cytokine secretion, cytotoxicity and proliferation

  • Experience with multi-color flow cytometry and flow data analysis is required, cell sorting experience a plus

  • Excellent computer skills and experience with Microsoft Excel, Flow cytometry data analysis software, and Graphpad Prism are essential

  • Demonstrated scientific leadership experience including leading cross-functional teams and execution of projects on time

  • Experience with molecular profiling and TCR sequencing is a plus

Education & Experience Required

  • PhD in cellular biology/immunology with a minimum of 2 years related biopharmaceutical  industry experience

Senior Research Associate, Translational Immunology

Position Summary

Genocea’s foundational technology, the ATLAS™ platform, is a high-throughput autologous cell assay that discovers T cell antigens thought to be important in fighting a patient’s disease.  ATLAS™ results are used to select validated neoantigens for a patient-specific vaccine. Our lead program, GEN-009, a personalized neoantigen vaccine, is in the clinic. The successful candidate will be an active member of a team that supports the evaluation of immunogenicity and efficacy of oncology vaccines in clinical trials.

We are seeking a seeking a Senior Research Associate in Translational Immunology who will play a critical strategic role in design and execution of complex immune-monitoring experiments with human clinical samples for GEN-009, using established and novel procedures. The candidate will be expected to be in the laboratory leading junior team members through research experiments and clinical testing. The candidate must have a strong, positive work ethic. The ideal candidate is a highly motivated, focused, detail-oriented person. Demonstrated hands-on experience with cell culture and immunological assay development is preferred.

Primary Responsibilities

  • Testing of Genocea clinical trial samples in immunogenicity assays

  • Design, develop and qualify/validate immunological assays to characterize vaccine therapeutic responses including: ELISPOT, multi-color flow cytometry and intracellular cytokine staining

  • Propose, plan and implement/execute experiments with minimal supervision

  • Follow new developments and technologies in the field of immuno-oncology

  • Develop and maintain good working relationships with RAs, scientists, statisticians, computational biologists, and external collaborators as part of a multidisciplinary team

Competencies

  • Excellent ability to perform hands on experiments and maintain detailed documentation

  • Excellent organizational skills and ability to multi-task and embrace change in an extremely fast-paced environment

  • Strong work ethic and good problem-solving ability

  • Ability to work as part of a team, collaborating and communicating effectively with members of other functional groups

  • Ability to train and mentor junior staff

  • A sense of humor is essential

Required Skills

  • Prior experience in performing immunoassays and hands on experience in cell culture

  • Ability to work independently and as a part of a cross-functional team with a positive attitude.

  • Strong verbal and written communication skills are required.

  • Ability to analyze data, draw conclusions, communicate results and compile technical reports.

  • Excellent record keeping abilities to adequately record and document analytical data.

  • Capacity to adapt, with a strong desire to learn new concepts and techniques

  • Experience with multi-color flow cytometry and flow data analysis is a plus

  • Excellent computer skills and experience with Microsoft Excel, Flow cytometry data analysis software, and Graphpad Prism are essential

Education Requirements

  • Master’s degree or bachelor’s degree with a minimum of 3-5 years of experience in biopharmaceutical industry.

Senior Quality Assurance Specialist Contractor

Position Summary

We are looking for a Senior Quality Assurance Specialist to support quality assurance activities in support of the manufacture, testing, and release of clinical product. The QA Specialist will review manufacturing batch records, deviations, change controls and disposition of clinical drug product. The Senior Quality Assurance Specialist is responsible for ensuring reviews of Manufacturing and Quality Assurance records are certified for compliance to in-house specifications/standards and Good Manufacturing Practices. In addition, the Sr. QA Specialist will work to identify key continuous improvement opportunities to ensure quality systems are aligned with business strategy, industry standards and global regulatory expectations.

Primary Responsibilities

  • Reviews manufacturing and support records to certify compliance with specifications and procedures

  • Assists Quality Assurance Management with product disposition activities.

  • Reviews and assesses deviations; includes performing risk assessments, participating in root cause analysis investigations, tracking, follow-up and reporting/trending

  • Works closely with Manufacturing and Analytical to resolve open issues resulting from record reviews and deviation issues

  • Work with all departments to ensure timely completion of manufacturing batch records, deviations, CAPAs, and change controls

  • Input batch/lot information into electronic databases and generate reports from these systems

  • Review Manufacturing batch records and completes required documentation for batch disposition

  • Create, revise and review Quality System documents, including Standard Operating Procedures, protocols, and reports

  • Performs data audits, as needed

  • Provide training to site personnel and contractors on GMP and quality system procedures, as needed

Competencies

  • Ability to prioritize daily activities in order to meet timelines in a fast-paced environment

  • Ability to monitor and report on assigned tasks, goals and objectives

Education & Experience Required

  • Bachelor’s degree in Life Sciences, or related field and 5 to 8 years experience in biopharmaceutical quality assurance

  • Excellent written and verbal communication skills

  • Experience with clinical product programs is required

  • Experience personalized medicine or cell therapy products is a bonus

Research Associate, ATLAS Screening and Development

Position Summary

Genocea is seeking a talented and dedicated Research Associate to join our dynamic and enthusiastic team. As part of the Discovery group, the Research Associate will support sample processing and characterization of T cell responses to support the development of novel immunotherapeutics for cancer, including personalized cancer vaccine clinical trials. The successful candidate will be highly motivated, diligent and detail-oriented, and have the ability to carry out experiments with limited supervision. Demonstrate the flexibility to adapt in a fast-paced environment and a strong desire to learn new concepts and techniques. Strong communication skills will be key to work well within a dynamic and team-oriented environment.

Primary Responsibilities

  • Diligently analyze data, prepare summaries, and present them for internal company meetings.

  • Troubleshoot issues during experimental process under supervision

  • Attends team meetings for experimental planning and provides progress updates to the group

  • Operation of liquid-handling robots

  • Blood processing and primary human cell culture

Competencies

  • Ability to work effectively in a cross-functional and diverse team

  • Strong organization skills and ability to multi-task

  • Excellent communication, problem solving and analytical skills

Required Skills

  • Hands-on experience with flow cytometry and/or cell sorting is preferred

  • Excellent record keeping abilities to adequately document protocols and experimental data.

  • A theoretical understanding of and significant experience with common techniques related to cellular immunology

  • Familiarity with cell imaging and liquid-handling robots

  • Ability to analyze data, draw conclusions, communicate results and compile technical reports

  • Capacity to adapt, and a strong desire to learn new concepts and techniques.

  • Prior experience in Immunological-based techniques including ELISA-based assays (e.g. MSD) and T cell assays mainly related to screening for vaccine candidates (e.g. cell sorting, multicolor flow-cytometry, ELISpot)

  • Maintain basic knowledge of principles in field(s) at hand

  • Maintain accurate laboratory records and notebooks

  • Multicolor flow-cytometry (surface and ICCS)

Education & Experience Requirements

  • Bachelor’s degree with a minimum of 2 years’ experience in immunology and/or cancer biology in academia or industry

  • Knowledge of advances in immunology, understanding of cancer biology is preferred

  • Experience in a high throughput screening environment is preferred

Senior Procurement Associate

Position Summary

We are seeking a Senior Procurement Associate responsible for managing purchasing activities throughout the procurement lifecycle and provide professional assistance to internal customers to achieve the greatest value for each dollar expended. Takes independent action to ensure deliveries are met and/or services are performed, standards are adhered to and that internal follow-up is achieved. Facilitate requests and interface with vendors.

Primary Responsibilities

  • Ensures accurate record keeping by administering and maintaining purchasing standards, policies and procedures, as well as the corresponding paperwork.

  • Review purchases to ensure adherence to business and policy compliance; work with end users to educate and resolve out of compliance purchases

  • Work with end users to develop specifications for equipment, services, materials and supplies to be purchased.

  • Identify and evaluate vendors of goods and services; develop alternate sources of supply as needed.

  • Leads and manages RFP process.

  • Establish delivery schedules, monitor progress and contact suppliers to resolve problems.

  • Evaluate and audit contract performance and terms to ensure compliance with terms and conditions.

  • Manage dispute and track dispute resolution process with suppliers as needed.

  • Continuously evaluate purchasing processes to identify opportunities for improvement and streamlining.

  • Lead and develop quarterly Procurement reporting package

  • Support teams by assisting with various cross departmental initiatives and projects

Competencies

  • Strong written, verbal, negotiation, forecasting and planning skills

  • Mature interpersonal skills with proven ability to interact with diverse audiences

  • Strong analytical skills

  • Ability to be creative and develop out-of-the-box solutions

  • Excellent communication and influencing skills

  • Excellent organizational skills

  • Ability to analyze, evaluate and present complex results to varied audiences

  • Ability to work independently and as a member of a team

  • Ability to manage multiple projects and priorities simultaneously

  • Independent judgment and action

Required Skills

  • Strong experience in Microsoft Office Suite. (Excel, PowerPoint, Word)

  • In depth knowledge of standard contract terms and conditions

  • Deep understanding of the procure-to-pay process

  • Proven positive experience working with vendors/customers

  • Manage multiple projects through completion of tasks; flexibility

  • Demonstrated experience in building purchasing/strategic sourcing programs from the ground up

Education Requirements

  • Bachelor's degree in Business Administration or related discipline

  • 5 to 7 years experience in a purchasing management or strategic sourcing capacity

  • Experience in NetSuite Procurement/Advanced Procurement module

  • Life Science industry experience a plus

Senior Computational Biologist

Position Summary

We are seeking a talented and highly motivated Sr. Computational Biologist to provide technical expertise and leadership in using advanced computational methods enabling immunology research, optimization of the ATLAS platform and supporting immune-oncology clinical trials. The successful candidate will possess the ability to work within a fast-paced multidisciplinary environment to drive development, implementation and maintenance of innovative computational tools support research and clinical initiatives.

Primary Responsibilities

  • Work within an interdisciplinary team of molecular biologists, cellular biologists, data scientists / statisticians and software engineers to support utilization and optimization of the ATLAS™ antigen discovery platform

  • Develop and implement automated methods and analytical tools to deliver insights and hypotheses from multi-dimensional biological data sets

  • Use established programming standards and best practices in building Bioinformatics tools

  • Present scientific and technical data to both internal and external scientific colleagues in a clear and cohesive manner

  •  Bring in original ideas to create solutions to complex problems

Required Skills

  • Experience in cancer, immunology research

  • Strong scientific understanding of cellular biology, molecular biology including experience with transcriptomics and cellular profiling data 

  • Experience in application of statistical techniques to biological data, experience in exploratory analysis

  • Experience in R programing and SQL

  • In depth knowledge of relevant public and proprietary databases, methods and tools (NCBI, UCSC Genome Browser, TCGA)

  • Demonstrated expertise in delivering insights and hypotheses from complex multi-dimensional biological data in a biomedical context.

  • Strong programming skills in Python

  • Process, analyze and interpret high volumes of cellular profiling data as part of internal and external scientific studies

  • Integrate innovative analysis and visualization tools for omics data sets, in the context of studies of cancer-patient samples

Education & Experience Requirements

  • Ph.D. in Bioinformatics, Computational biology or other related fields

  • 2+ years of relevant post-graduate research experience, including biotech/pharma experience

  • Demonstrated expertise in genomic data analysis

Biostatistician

Position Summary

We are seeking a talented and highly motivated Data Scientist with strong statistical expertise. The successful candidate will provide technical expertise and leadership to use advanced statistical methods enabling immunology research, optimization of the ATLASTM platform and supporting clinical trials. The successful candidate will also possess the ability to work within a fast-paced multidisciplinary environment to drive development, implementation and maintenance of innovative computational tools to support research and clinical initiatives.

Primary Responsibilities

  • Work within an interdisciplinary team of molecular biologists, cellular biologists, computational biologists / data scientists and software engineers to support utilization and optimization of the ATLAS™ antigen discovery platform

  • Work closely with Computational Biology expertise to add statistical rigor to analyses

  • Bring strong statistical expertise to team along with skills / aptitude in developing data processing pipelines

  • Integrate statistical solutions into Bioinformatics pipelines using established programming standards and best practices

Competencies

  • Ability to work independently in a multidisciplinary, fast-paced, dynamic and results-oriented environment

  • Excellent teamwork, time management and organizational skills

  • Demonstrated ability to present data to a multidisciplinary audience in a clear and cohesive manner

  • Develop understanding of multi-dimensional biological and clinical data sets

  • Create innovative statistical solutions to address relevant questions

Required Skills

  • Experience in analyzing biological and clinical datasets

  • Experience in R programming and SQL

  • Process, analyze and interpret high volumes of cellular profiling data as part of internal and external scientific studies

  • Integrate innovative analysis and visualization tools for omics data sets, in the context of studies of cancer-patient samples

  • Present scientific and technical data to both internal and external scientific colleagues in a clear and cohesive manner

  • Work independently and prepare timetables, deliverables, and project schedules

  • Demonstrated expertise in delivering insights and hypotheses from complex multi-dimensional biological data in a biomedical context

Education & Experience Required

  • Ph.D. Statistics, Biostatistics, Mathematics, Bioinformatics or other related fields

  • Strong programming skills in Python

  • 1+ years of relevant post-graduate research experience, including biotech/pharma experience