Research Associate, Immunology & Preclinical Studies

Position Summary

We are seeking a motivated Research Associate to join our team developing next-generation vaccines and cellular therapies in immuno-oncology. The successful candidate will work on modeling ATLAS-based antigen selection in preclinical tumor models and carry out IND-enabling preclinical studies to advance immunotherapy programs to clinical trials. The position is lab-based and will work in collaboration with multiple team members. The ideal candidate will have experience in immunology and oncology and will have demonstrated hands-on experience with animal handling, cell culture and immunological assays, such as ICS, ELISPOT, and flow cytometry. Critically, we are looking for an energetic, detail-oriented, and committed individual that is passionate about research and the opportunity to positively impact patient lives.

Primary Responsibilities

  • Ex vivo ATLAS bioassays to identify neoantigens in syngeneic mouse tumor models 

  • Develop methods for isolation and expansion of mouse T cells including immune cell enrichment, T cell culture, APC differentiation and maturation

  • In vivo immunogenicity and tumor efficacy experiments to test vaccine and cellular therapy candidates

  • Immunological assays to characterize therapeutic response including: multi-color flow cytometry, intracellular cytokine staining, ELISpot, ELISA, immunohistochemistry, and tumor infiltrating lymphocyte analysis

  • Develop and maintain good working relationships with RAs, scientists, statisticians, computational biologists, and external collaborators as part of a multidisciplinary team.

COMPETENCIES

  • Strong communication, presentation and writing skills with an ability to explain complex technical details in simple language.

  • Ability to perform hands on experiments, organize studies, and maintain detailed documentation

  • Excellent organizational skills and ability to multi-task and embrace change in an extremely fast-paced environment

  • Independently motivated, detail oriented with good problem-solving abilities

  • Ability to work as part of a team, collaborating and communicating effectively with members of other functional groups

  • Curiosity and excitement for learning a new and challenging scientific field

Required Skills

  • Hands-on experience with in vivo animal studies and mammalian cell culture

  • A solid theoretical understanding of and experience with immunology techniques such as ELISpot, ELISA, and flow cytometry 

  • Ability to analyze data, draw conclusions, communicate results and compile technical reports.

  • Ability to work independently and as a part of a cross-functional team with a positive attitude.

  • Strong computer skills and experience with Microsoft Office and Graphpad Prism

  • Experience with flow cytometry and flow data analysis is a plus

  • Strong background in immunology and oncology is a plus

  • Molecular biology expertise is a plus

Education Requirements

  • Master’s or bachelor’s degree with an additional 1 yr of academic or industry experience