We are seeking a motivated Research Associate to join our team developing next-generation vaccines and cellular therapies in immuno-oncology. The successful candidate will work on modeling ATLAS-based antigen selection in preclinical tumor models and carry out IND-enabling preclinical studies to advance immunotherapy programs to clinical trials. The position is lab-based and will work in collaboration with multiple team members. The ideal candidate will have experience in immunology and oncology and will have demonstrated hands-on experience with animal handling, cell culture and immunological assays, such as ICS, ELISPOT, and flow cytometry. Critically, we are looking for an energetic, detail-oriented, and committed individual that is passionate about research and the opportunity to positively impact patient lives.
Ex vivo ATLAS bioassays to identify neoantigens in syngeneic mouse tumor models
Develop methods for isolation and expansion of mouse T cells including immune cell enrichment, T cell culture, APC differentiation and maturation
In vivo immunogenicity and tumor efficacy experiments to test vaccine and cellular therapy candidates
Immunological assays to characterize therapeutic response including: multi-color flow cytometry, intracellular cytokine staining, ELISpot, ELISA, immunohistochemistry, and tumor infiltrating lymphocyte analysis
Develop and maintain good working relationships with RAs, scientists, statisticians, computational biologists, and external collaborators as part of a multidisciplinary team.
Strong communication, presentation and writing skills with an ability to explain complex technical details in simple language.
Ability to perform hands on experiments, organize studies, and maintain detailed documentation
Excellent organizational skills and ability to multi-task and embrace change in an extremely fast-paced environment
Independently motivated, detail oriented with good problem-solving abilities
Ability to work as part of a team, collaborating and communicating effectively with members of other functional groups
Curiosity and excitement for learning a new and challenging scientific field
Hands-on experience with in vivo animal studies and mammalian cell culture
A solid theoretical understanding of and experience with immunology techniques such as ELISpot, ELISA, and flow cytometry
Ability to analyze data, draw conclusions, communicate results and compile technical reports.
Ability to work independently and as a part of a cross-functional team with a positive attitude.
Strong computer skills and experience with Microsoft Office and Graphpad Prism
Experience with flow cytometry and flow data analysis is a plus
Strong background in immunology and oncology is a plus
Molecular biology expertise is a plus
Master’s or bachelor’s degree with an additional 1 yr of academic or industry experience