We are seeking an innovative Scientist to join our team developing novel immunotherapies for cancer. Genocea’s foundational technology, the ATLAS™ platform, is a high-throughput autologous cell assay that discovers T cell antigens thought to be important in fighting a patient’s disease. ATLAS™ results are used to select validated neoantigens for a patient-specific vaccine, and upon population-based screening can identify antigens to include in a common vaccine. Our lead program, GEN-009, a personalized neoantigen vaccine, will soon be in the clinic. The successful candidate will advance the next generation of ATLAS screening. The Scientist will design, develop, execute and analyze T cell and dendritic cell culture studies to improve cell viability and recovery. In addition, the candidate will develop multicolor flow cytometry assays to determine the phenotype and functionality of cells. The position is lab-based and will work in collaboration with other teams. The Scientist will have the ability to independently troubleshoot technical issues and develop optimized processes and assays for critical tasks. The successful candidate will have a strong background in immunology and T cell biology. The scientist will have demonstrated hands-on experience with cell culture and immunological assays, such as ICS, ELISPOT, immunophenotyping, cell sorting and flow cytometry.
Develop method for isolation and expansion of human T cells including immune cell enrichment, T cell culture, APC differentiation and maturation and cryopreservation
Develop, optimize and qualify immunological methods to ATLAS development such as ICS, proliferation, cytotoxicity, cell sorting and multi-color flow cytometry assays
Experimental troubleshooting and development of improved workflows suitable for research and clinical application.
Design and perform DOE experiments to further characterize and optimize assays
Mentor junior members of the team
Follow new developments and technologies in the field of immuno-oncology.
Excellent ability to perform hands on experiments, research, design, and organize project designs and maintain detailed documentation
Excellent organizational skills and ability to multi-task and embrace change in an extremely fast-paced environment
Independently motivated, detail oriented and good problem-solving ability
Ability to work as part of a team, collaborating and communicating effectively with members of other functional groups
Strong writing, editing and presentation skills required
A sense of humor is essential
Expertise and hands-on experience in mammalian cell culture with specific experience culturing primary T lymphocytes and dendritic cells is a requirement
Strong background in T cell biology and immunology is required, with background in oncology a plus
Demonstrated experience with immunological assays to assess and characterize T cell function such as cytokine secretion, cytotoxicity and proliferation
Experience with multi-color flow cytometry and flow data analysis is required, cell sorting experience a plus
Excellent computer skills and experience with Microsoft Excel, Flow cytometry data analysis software, and Graphpad Prism are essential
PhD in cellular biology/immunology with a minimum of 2 years related academic or industry experience
MS in cellular & molecular biology/immunology with a minimum of 7 years related academic or industry experience