Scientist, Immunology Assay Development

Position Summary

We are seeking an innovative Scientist to join our team developing novel immunotherapies for cancer.  Our lead program, GEN-009, a personalized neoantigen vaccine, is in the clinic.  The Immunology/Assay Development Scientist will be expected to design and execute complex immune monitoring experiments with human clinical samples utilizing established and novel procedures. The candidate will have demonstrated hands-on experience with assays, such as ICS, ELISPOT, and other cell-based immunological assays such as immunophenotyping.  He/she will have experience with assay development, troubleshooting, qualification, validation and clinical testing.  The successful candidate will supervise a team that supports the evaluation of immunogenicity and efficacy of oncology vaccines in clinical trials. The candidate will demonstrate effectiveness as a team member and write experimental and clinical protocols and reports for senior management.  The candidate will be expected to be in the laboratory to perform experiments and clinical testing with other team members.  The candidate must have a strong, positive work ethic and be highly collaborative with other group members.  The successful candidate will have a strong background in immunology and T cell biology. 

Primary Responsibilities

  • Select appropriate methodologies and design, develop, and qualify/validate applications/assays in support of vaccine research projects.  Design and run the development of assays to evaluate cell-mediated immune responses in clinical samples. Propose, plan and implement/execute experiments with minimal supervision.

  • Provide technical resources for immunology method development, optimization, implementation and validation.

  • Ability and willingness to work in the laboratory to perform human clinical testing and meet deadlines.

  • Work collaboratively with Translational Medicine and other team members to understand their deliverables to achieve organization goals.

  • Demonstrated experience with method development, qualification and validation is necessary.

  • Follow new developments and technologies in the field of immuno-oncology.

Competencies

  • Excellent ability to perform hands on experiments, research, design, and organize project designs and maintain detailed documentation

  • Excellent organizational skills and ability to multi-task and embrace change in an extremely fast-paced environment

  • Independently motivated, detail oriented and good problem-solving ability

  • Ability to work as part of a team, collaborating and communicating effectively with members of other functional groups

  • Strong writing, editing and presentation skills required

  • Demonstrated experience with direct management of multiple reports is essential.

  • Ability to hire, train, and mentor staff

  • A sense of humor is essential

Required Skills

  • Strong background in T cell biology and immunology is required, with background in oncology a plus

  • Demonstrated experience with clinical testing

  • Experience with assay development and qualification

  • Demonstrated experience with immunological assays to assess and characterize T cell function such as ELISPOT, cytokine secretion, cytotoxicity and proliferation

  • Experience with multi-color flow cytometry and flow data analysis is required, cell sorting experience a plus

  • Excellent computer skills and experience with Microsoft Excel, Flow cytometry data analysis software, and Graphpad Prism are essential

Education Requirements

  •  PhD in immunology with a minimum of 2 years related industry experience