Scientist, Synthetic Biology

Genocea Biosciences is an immuno-oncology biotechnology company focused on bringing personalized cancer vaccines to patients. Using our revolutionary ATLAS™ platform we are creating new lifelines for cancer patients by listening to and learning from their immune system.  ATLAS™ is a high-throughput bioassay that utilizes a patient’s own immune system to identify T cell antigens that are critical to fighting disease. In the case of cancer, the ATLAS platform identifies which patient-specific tumor neoantigens are optimal for recognition by the patient’s immune system and inclusion in a vaccine or immunotherapy. A Phase 1/2a clinical trial of Genocea’s GEN-009 personalized vaccine is ongoing. Genocea is also developing a broad pipeline of cancer immunotherapy candidates. 

The synthetic biology team is seeking an exceptionally creative Scientist with expertise in advanced synthetic biology and cell culture techniques to lead the development of novel antigen screening strategies.  The ideal candidate will generate innovative solutions by drawing inspiration from diverse fields of biology, to design, test, and implement novel bioassays.  Effective communication skills will be key to work well within a dynamic and team-oriented environment.

Primary Responsibilities

  • Drive the design of a novel antigen screening strategy from the ground-up by engaging an interdisciplinary team of molecular, cellular, and computational biologists.

  • Independently plan and execute experiments supporting the development of the new bioassay platform.

  • Generate ATLASTM libraries in support of clinical trial and research screening campaigns.

  • Identify and contribute to experiments designed to increase the efficiency and throughput of ATLASTM.

  • Present scientific and technical data to both internal and external scientific colleagues in a clear and cohesive manner.

  • Mentor junior team members at the bench with the potential for management responsibility in the future.

  • Ensure scientific integrity and documentation of experimental data to meet standards suitable for intellectual property, FDA submissions, and publication.

Required Skills

  • Expertise in advanced synthetic biology approaches (reporter systems, DNA barcoding, etc.) and molecular biology techniques (NGS, gene variant library design and cloning, qPCR, etc.).

  • A demonstrated record of identifying and developing creative approaches to difficult problems.

  • Expertise in bioinformatics, genetic and genomic analysis, data and literature mining, disease and biological pathway analysis.

  • In depth knowledge of relevant public and proprietary databases, methods, and tools (NCBI, UCSC Genome Browser, IGV).

  • Strong writing, editing, and presentation skills required.

  • Ability to work as part of a team, collaborating and communicating effectively with members of other functional groups.

  • Excellent organizational skills and ability to multi-task and embrace change in an extremely fast-paced environment.

  • Experience in immunology, oncology, and/or laboratory automation is a plus.

Education Requirements

  • Ph.D. in Molecular Biology, Cellular Biology, Genomics or other related fields with relevant post-graduate research experience.

  • Additional 1 – 3 years of industry experience.