Infectious Diseases

Pneumococcus

GEN-004 is a novel T cell vaccine developed from Genocea’s ATLAS™ technology. It is aimed at preventing colonization of the upper airway by all serotypes of pneumococcus. Pneumococcal infections are the leading cause of death in children under age five. Instead of preventing infections caused by only a small number of serotypes of pneumococcus as vaccines currently available on the market do, GEN-004 is designed to provide protection against each of the more than 90 serotypes of pneumococcus, thereby offering potentially universal protection against pneumococcal disease.

Genocea announced top-line results from a Phase 2 clinical trial for GEN-004 in 2015. GEN-004 showed consistent reductions versus placebo in the pre-specified endpoints of the rate and density of colonization, but neither of the endpoints achieved statistical significance.

Genocea is currently seeking development partners to advance GEN-004 further.

Chlamydia

Infections by the bacterium Chlamydia trachomatis are a significant cause of morbidity worldwide. Chlamydia is the most common cause of bacterial sexually transmitted disease accounting for approximately 3 million new infections each year in the United States alone and more than 100 million new infections each year globally. Cellular immunity through T cells is believed to be critical for managing and potentially preventing infection from chlamydia.

Genocea’s ATLAS platform has been utilized to screen the T cell immune responses of hundreds of human subjects exposed to chlamydia. As a result, we have identified chlamydia antigen targets that elicit T cell responses preferentially in patients with positive clinical outcomes. These antigen targets, associated with an effective human immune response, could become the core of a therapeutic or prophylactic vaccine that could dramatically improve infection control and reduce the spread of disease worldwide.

Genocea is currently seeking development partners to explore further development of a Chlamydia therapeutic vaccine.

Malaria

Malaria is one of the deadliest infectious diseases in the world. In 2012, more than 600 million cases of malaria were reported by the World Health Organization (WHO), claiming over 600,000 lives, many of them children and largely in developing countries.

Upon infection, the malaria parasite rapidly replicates in the liver. T cells in the liver could potentially kill the cells in which the parasite is hiding before the parasite is released into the bloodstream. Genocea’s T cell target discovery platform, ATLAS, has been applied to identify which components of the malaria parasite can act as T cell targets and become part of novel vaccine candidates.

The malaria program has been funded partially by the U.S. Department of Defense and the Bill and Melinda Gates Foundation.

Genocea is currently seeking development partners to explore further development of a malaria therapeutic vaccine.

Other Infectious Disease Publications and Presentations